Now we just eat off him, and when I talk to Em
A smile comes on his face, he told me here's the case
''Enemies stay enemies but friends they change
Niggas go crazy over money, my mane''

from 50 Cent – So Disrespectful Lyrics on Rap Genius

Meaning

Eminem’s response to 50’s feud was the classical thought of friends developing into enemies — just like what happened with Tupac and The Notorious B.I.G

The last line sums up the whole song, every feud he discussed in this song was mainly due to money.

Niggas go crazy over money, my mane

This subject is also covered in the Bible

For the love of money is the root of all evil

The thought of friends turning enemies was also addressed by Wu-Tang Clan’s Ghostface Killah in “Enemies All Around Me”

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