No more she lives no more serpent in her room
No more he has killed Cleopatra
It is generally believed that Cleopatra committed suicide by, as was the practice at the time, inducing a cobra (or asp) to bite her
The serpent is also the symbol of treason and disloyalty. Her angry lover compares her to a serpent in this sentence; since Cleopatra lived in her room one can infer that she and the serpent are one and the same. “No more it has killed Cleopatra” refers to two aspects: Her death by means of the serpent, and her serpent-like character which was the cause of her demise.
The serpent could also be symbolic of the man with whom Ocean’s love interest was unfaithful. Cleopatra’s “death” here could refer to his love interest figuratively being dead to him because of her actions. Simply put, the snake (the man) bit (had sex with) Cleopatra, causing her death (Ocean feeling nothing for her anymore).
“he” could also be The Man who continues to advertise the controlling image of the black female body as an object for consumption, hypersexual subjectivity and dishonor in popular media.
To help improve the meaning of these lyrics, visit "Pyramids" by Frank Ocean Lyrics and leave a comment on the lyrics box