The white man can't even go outside
He'll get a disease

from Das Racist – All Tan Everything Lyrics on Rap Genius

Meaning

The white man can’t think outside himself without “feeling weird.”

Historically, White Europeans visiting “the colonies” would easily catch and die from illnesses to which the locals were resistant or immune. Nothing to do with this, even though it may be true.

The literal disease being referenced is skin cancer as stated in the next lines. “I’m talking about… that skin cancer”

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