And the moon is my only homie

from Hopsin – Nocturnal Rainbows Lyrics on Rap Genius

This means he is so lonely that his only friend is the moon. Another interesting fact is that the moon is known to resemble a human face, so it could really look like a person to Hopsin, therefore it is his friend.
This is also a reference to Hopsin’s debut album, Gazing At the Moonlight.

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