Come, listen, yeah I can be your E-pill
Better yet your He-pill, when it come to tricking D-pills

from A$AP Rocky (Ft. ASAP Ferg) – Get High Lyrics on Rap Genius

Meaning

E-pill (Ecstasy/MDMA) referring to the actual drug, offering to get her some. Better yet, Ferg can be your HE-pill (your man or sexual escapade for the night) and give you his D-pill, “D” being a popular way of saying dick.

Ecstasy or “Molly” seems to be a popular drug reference for rappers, most famously and recently on the G.O.O.D Music posse cut Mercy.

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