40 killings in a weekend, 40 killings in a week

from Kanye West (Ft. Ghostface Killah & Pusha T) – New God Flow Lyrics on Rap Genius

Meaning

Chicago, especially the poorer neighborhoods, is known for a lot of things especially the violence and killings that happen there.
Kanye also speaks of this in the song “Murder to Excellence”

“40” foreshadows the Noah’s Ark references a few lines later, as Noah and his crew had to survive 40 days and 40 nights without drowning.

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