I'm stressed, smoking weed and nicotine

from Thug Life (Ft. 2Pac & Stretch) – Under Pressure Lyrics on Rap Genius

Meaning

He relieves his stress by smokin weed and nicotine, being cigarettes.

Also a play on words, since all these are forms of narcotics from the stress (low-tier level weed) to cigarettes (nicotine).

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