Before I can let the smoke out, niggas let twenty go

from Game (Ft. Latoya Williams) – Never Can Say Goodbye Lyrics on Rap Genius

Meaning

This line makes two factual assertions about the Tupac shooting. First, he was likely smoking at the time of the shooting. Second, the assailants fired 20 bullets at Tupac.

Here is the car in which Tupac was riding, shown riddled with bullet holes after the shooting:

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