But if you think you’re fucking with me, homie, you’re on one

from Eminem – Seduction Lyrics on Rap Genius

Meaning

The only way that you could actually believe that you can actually beat Em’s flows or his ability to steal your girl is if you were on drugs.

Just to be clear, the track “I’m On One” by Lil Wayne, Drake, and Rick Ross came out almost a year after this song. So while it’s not out of the question that he might be dissing some of them in the rest of the song, this line isn’t a reference to that song.

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