Wayne will make the vagina sing. His girls are much wilder, so “Lion” is used as an alternative to the overused and much too tame “pussy”
Lions are known to be “Big Cats” and by saying this Lil Wayne is saying that he is a statue of person that can make a big cat do something that ordinary/small cats do. This is metaphor for a well respected person, as in he can make someone who is “Big” do something that is uncharacteristic of them. Even if that person is at the top of the food chain as a Lion is.
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