50 is saying that he will shot you with his P90 Ruger

Many wild animals have been susceptible to a brain disease called rabies. When the virus attacks the brain cells, it causes the salivary gland to overproduce saliva, causing foaming at the mouth

To put it shortly, when an animal has rabies, it is “spitting” and is crazy. A slang term for rapping is “spitting”, and he is saying whenever he raps it’s incredible, or insane

Explanation author: werdna777777

Slim Shady(izzle), aka Eminem, does not give a FUCK!

How do you know this?

His previous songs — “I Just Don’t Give a Fuck” and “Still Don’t Give a Fuck” — might be the first clue..

Explanation author: Maboo

Eminem paraphrases Snoop’s -izzle (“wizzle” instead of “nizzle”, since Eminem is forbidden from using even the -izzle version of the N-word) as a symbol of pop-rap crossoverism

In this line, Em is just saying “is it a miracle that I was successful, or a perfectly normal and logical cause / effect?” Pop fizzing up is not a miracle, it’s a normal occurrence because soda is fizzy

He could also be reflecting on the brief nature of pop stardom; soda fizz is composed of bubbles which disappear into thin air once they reach the top

Eminem tries to avoid pop music — to no avail

Em is reflecting on whether his success was caused by a miracle or by the decline of the pop music genre. Artists like N'Sync, Backstreet Boys, Britney Spears, Christina Aguilera, dominated the mainstream airwaves for years until the early 2000s when hip hop and R&B took over mainstream music. This shift coincided with the 1999 release of Eminem’s “Slim Shady LP” and his subsequent rise to fame

Explanation author: Maboo

What Em is really saying is that through his verses, through his skills and through his life in fame, has been trying to demonstrate an innate truth that all great spiritual men and women have been trying to tell us: that the spirit of God dwells within us. I.E. the kingdom of heaven, etc. He is not saying he is the direct savior of hip hop

Explanation author: Jumtheory

Eminem’s one of the few rappers alive that is compared to legendary rapper, Tupac Shakur. The line implies that he wants Tupac listeners to see that he’s also dope MC whether they like it or not

Explanation author: Kakarot

Em took 2Pac’s audience after he died, with only a minimal swap (his skin color)

Of course, 2Pac had much more muscle-mass as well, but we won’t quibble.

Explanation author: Shadowcast

Em is a criminal (as he made clear in the song “Criminal”) — he’s killing the villains (the less “ill” rappers) of the rap game

All of these are descriptions of himself, he is a criminal, and a cop killing hip hop villain

Explanation author: Snibunny

Amoxicillin is a generic relative of penicillin, tying in with the previous line

The mocks/mox sound might also bring to mind a “mockup” (an inferior copy of something)

Explanation author: neander7hal

In the live version 50 changes “enough” of the original track for “Eminem”

Even if Eminem mainlines prescription antibiotics — the way that adrenaline is delivered — they still won’t cure his “illness” (meaning the quality of his rap)

Explanation author: neander7hal