This is a reference to the opening line of the Doors' song “Peace Frog”:

There’s blood in the streets, it’s up to my ankles
Blood in the streets, it’s up to my knees

Carpe diem! Weezy has hinted that he may retire after this album, so he goes hard on the track because it may be his last. This is a contrast to what he was saying about retirement during his Dedication 2 days:

http://www.youtube.com/watch?v=b_Qj69b8YyE

A reference to MC Breed’s 1991 hit, “Ain’t No Future In Yo' Frontin'”.

The “save/memory card” video game pun has been around for quite a while – DOOM used it on his 2003 song “The Drop”:

Remember me, God, clean Timbs with emery board?
He only came to save the game like a memory card

Wayne, in a rarity for hip-hop, provides a not-that-terrible sex worker reference. This is not entirely out of character for Weezy – he was not at all upset when 50 Cent called him a whore in 2008

Guru here refers to popular theories about the creation of the crack epidemic and the spread of the AIDS virus:

– The idea that the U.S. government created , popularized by journalist Gary Webb in a series of stories in 1996, that, as Wikipedia puts it,

Nicaraguan drug traffickers had sold and distributed crack cocaine in Los Angeles during the 1980s, and that drug profits were used to fund the CIA-supported Nicaraguan Contras. Webb never asserted that the CIA directly aided drug dealers to raise money for the Contras, but he did document that the CIA was aware of the cocaine transactions and the large shipments of cocaine into the U.S. by the Contra personnel

The story, while initially retracted by the newspaper that printed it, has in some respects come to be vindicated. See this PBS report for a measured look at exactly what the CIA likely knew, didn’t know, and/or didn’t want to know. You can read Webb’s original stories here

Guru was way ahead of his time here, as this song was released four years before the Webb stories were published, though news reports of the Contras' involvement in cocaine trafficking had been around since the 1980’s

– There have been long-running conspiracy theories that AIDS was somehow manufactured by the government as a weapon against people of color. While this is certainly plausible given the history of race relations in this country, it is most definitively not true, and its spread continues to harm people who might otherwise be free of or get treatment for the virus. See David Gilbert’s excellent essay “AIDS Conspiracy? Tracking Down the Real Genocide” here for a valuable but respectful debunking of this particular conspiracy

G.W. Bush eventually laid blame for his invasion of Iraq on faulty intelligence claiming that the country had weapons of mass destruction, which were never found

While it is true that 22 Bin Laden family members were allowed to fly out of the United States on September 20th, 2001, it is not true, as is often claimed (and implied here), that they were not questioned regarding potential terrorism links or that they got any kinds of special permission to leave the country. The family members were in fact questioned and left on a legal charter flight one week after air traffic had resumed. See a thorough debunking of these myths here

It is true, however, that the Bushes have close and lucrative ties to the Saudi royal family, and long-running, if very distant, links to the Bin Laden family

On the morning of September 11th, 2001, Bush infamously remained with the Florida schoolchildren he was visiting for seven minutes after being told of the second airplane hitting the Trade Center

A 2010 poll of presidential scholars by the Siena Research Institute ranked G.W. Bush the fifth-worst President of all-time