Lloyd Banks, Tony Yayo, Game are/were members of G-Unit. Around this time, the three were making waves (with 50’s help) — Banks' The Hunger for More went platinum, Yayo had moderate success with his single “So Seductive” and Game’s The Documentary went double platinum and had two top five singles — both featuring 50.
As for 50: In 2005 (when this song was released), 50 Cent was making ~$32,000,000 — making him the second wealthiest rapper at the time, behind Jay-Z.
50 twists the chorus of “New York” to make Ja look like a pussy, by changing a line, originally: “I got a hundred guns, a hundred clips, nigga, I’m from New York”
“Takeover”, one of the most infamous diss tracks recorded, had Jay-Z taking shots at Nas and Prodigy from Mobb Deep — the song effectively squashed Prodigy’s career.
Ja Rule took shots at 50, Dre and Eminem on a diss track entitled “Loose Change” (50 Cent, loose change… get it?). At the very end he spits the lines: “Em, ya claim ya mother’s a crackhead and Kim is a known slut / so what’s Hailie gon' be when she grows up?” (Really bad move on his part)
Eminem’s emphasizing the size of his balls just to show how much of a fuck he could give about what you think (and, at the same time, giving an excuse as to why he has a small dick!)
Two big red flags:
1) You’re hearing voices.
2) You interpret this as a sign that you’re schizophrenic.
If you’re that gone, might as well make the best of it. (I wonder what it would be like to fuck hallucinations…)
7 million copies of 2001 sold later, Dr. Dre has since changed his mind.