These lines might reveal some information about Uncle Ronnie’s death. Uncle Ronnie’s suicide might be related to a girl, which is also mentioned in this article.
The third verse is a tape which was recorded by Stan, where he says that Eminem could’ve saved him.
Eminem doesn’t even get to listen to the tape, before he answers Stan.
The last hook is slightly different from the first two ones:
Replace all “my"s by "our"s and "she” by “they”.
The person he’s talking to represents the drugs he was taking.
And these drugs have taken his breath away once, when he had an overdose.
Instead of “homie this sick” it should be “homey they sick”.
I think the lyrics should be “I wanna get kissed, kissed […]”.
This would make sense, because it matches the very last line of the song
“Bieber” is german and means Beaver in english.
This means, that it isn’t a big deal for him to get head.
So it will almost be forgotten tomorrow.
he actually murders her in “Kim” and gets rid of her body in “‘97 Bonnie and Clyde”.
A reference to Biggie Small’s Everyday Struggle:
“Another day, another struggle”.