Clever saying that he’s never satified but when he is, it is never ending. Meaning there may always be something for him to improve on.
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Drake’s shoutout to Mac Dre is also because Dre used the term “you only live once” on his song “All I Want to do”.
So he’s basically paying homage in a way.
http://www.youtube.com/watch?v=gLff1j3b1IY