The ominous first lines of the song lead Buckley to explain an unhealthy addiction that is most likely to be attributed to an emotionally hurtful woman, and drugs.

Although it is disputed that Buckley used drugs regularly, as this Rolling Stone epitaph of him shows, Mojo Pin in particular is a song that includes obvious drug imagery.

Since his father, singer Tim Buckley, whom he only met once, died of a Heroin overdose, Jeff was apparently reluctant to use any drugs.

So it could also mean he just uses the drug imagery to shine a light on the similarities between drug and romantic addictions

Buckley is deeply affected emotionally by the woman’s scorn towards him.

“Hell hath no fury like a woman scorned,” stated famous playwright William Cosgreve.

A “Mojo Pin” is Buckley’s nickname for syringe of heroin. In a 1994 interview, Buckley commented on the origin of Mojo Pin:

Plainly speaking, it’s a euphemism for a dropper full of smack that you shoot in your arm,"

According to his fanpage mojopin.org, Jeff also gave different explanations on the term:

Sometimes if somebody you feel you need… the whole universe tells you that you have to have her, you start watching her favorite TV shows all night, you start buying her the things she needs, you start drinking her drinks, you start smoking her bad cigarettes, you start picking up her nuances in her voice, you sleep in safe sometimes the most dangerous thing… this is called Mojo Pin.

Teenagers typically don’t have many choices in life. They’re usually forced to comply with their parents' and teachers' demands. So this girl’s argument for them running away together is that unlike nearly everything else in life, this is the one thing they CAN choose.