This is a double entrendre.

Michael Vick is a professional NFL quarterback. At one point, he set the record for highest paid NFL player ever when he signed a $130 million dollar contract with the Falcons. He became the first NFL player to get two $100 million contracts, when he signed a second one with the Eagles in 2011, two years after this song’s release.

However, Vick eventually went bankrupt because he was convicted of operating an illegal dogfighting ring, including financing the project and personally executing between six and eight dogs. He served 21 months on a two-year sentence and has since returned to the NFL.

Ergo, Ross could be referring to the fact that Vick is one of the highest paid NFL athletes, or the fact that Vick paid for his crimes.

Probably a reference to a phrase that his Lil Wayne uses on a regular basis. Wayne often says that people can’t see him because “the money in the way”. This concept is often used in rap to express how immensely successful the artist has become and cannot even be bothered by those with smaller bank accounts.

Continuing with the theme of rhyming “22” with “22”, Ross denotes that his female friend is 22 years of age.

These “22” lines were used as criticism against Ross, because of it’s extreme simplicity.

Miami is notorious for it’s cocaine dealing, hence why the city is nicknamed M.I.YAYO, yayo being a Spanish slang word for cocaine.

The Boobie Boys were known to run Carol City’s drug scene. Ross was a member of the Boobie Boys and was supposedly Boobie Williams' protege.