Yes, Nicki is the boss. What she implies here, with the use of opposites, is that she is a girl (which in this business would be the weaker part), but she still manages to murder these sanctimonious creatures by using her cunning wits to create fatal bars.
For the men who want to sleep with her, she decides if they can or not, making them beg for it like little boys.
Furthermore, Little Boy was the codename for the type of atomic bomb dropped on Hiroshima in 1945. She ain’t playing around.
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Nicki did a song with Gucci Mane known as “Pussy Nigga.” This song and that one share similar lyrics (“Pussy this, pussy that”). She is saying that she couldn’t have sex with a “pussy nigga,” referencing Gucci Mane. This is denying his earlier 2013 claims that they had sex.