Some clever and funny wordplay by Royce, he wants this girl to give him “brain” (a blowjob) for so long that she won’t have any brains left for herself.
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The Gorillaz are likening the brainwashing of the children to be soldiers to them being turned to fire, as the destructive capabilities of them are similar to fire.
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In football, fullbacks are often larger runningbacks who are used to “bust through” the defensive line to gain short yardage. Deck compares this to the damage done by his pistol.
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Fullbacks seldom run the ball. In fact, they are usually used as the lead blocker in running plays. When the fullback is leading the charge, they are being followed by the ball carrier.
Hence, INS is alluding to the fact that, in this song, he has the first verse and is being followed by his fellow Wu members. A nice way to cap off his verse.