Em took 2Pac’s audience after he died, with only a minimal swap (his skin color)

Of course, 2Pac had much more muscle-mass as well, but we won’t quibble…

This line may also be referring to how his first album, Infinite flopped, forcing him to ‘swap’ personas; turning him into Slim Shady. This is what made Pac listeners listen to his stuff.

This metaphor alludes to Eminem’s misogynistic lyrics. Like a spider, Eminem uses webs and venom to catch women and make them his preys.

He uses the slang “hock a loogie"—which means to cough loudly and spit out phlegm—replacing the phlegm ("loogie”) with venom. This references the venomous lyrics he spits about women. The way he pronounces “hock” also sounds a lot like coughing phlegm.

Another interpretation is that he is referring to rival MCs as “women,” not an uncommon metaphor in the rap world at the time.

“Dun” is Queensbridge slang for “son” or “homeboy.” The “Dun language” came from a friend of Prodigy and Havoc that had a speech impediment, which made him pronounce “th” and “s” sounds as “d.” Prodigy explained:

One of our mans that we grew up with named Bumpy, he used to talk kinda of crazy. He had a speech impediment, but certain things he’d say were cool to us, so it became popular and everybody started mimicking how he’d talk. It just started from there, and we called it the dun language. Everything with a ‘s’, like if he said ‘Ayo son,’ it’d be, ‘Ayo dun.’ We just started doing it, and then the whole ‘hood started doing it, and we put it in our songs – the next thing you know, you’ve got Ben Stiller and Puffy [in a video] saying, ‘Yo dun, what up.

A “Philly” refers to a Philly Blunt—a popular cigar that is gutted and used to smoke marijuana with.