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- Royal Flush by Big Boi (Ft. André 3000 & Raekwon) prod. by The Flush
- Second Nature by Destiny's Child prod. by D'Wayne Wiggins, Jay Lincoln & Terry T
- Secret Lover by The Isley Brothers (Ft. Avant) prod. by Steve "Stone" Huff
- Sensitive Lover by The Isley Brothers prod. by Angela Winbush & Ronald Isley
- Sensuality by The Isley Brothers prod. by The Isley Brothers
- Sensuality (Live) by The Isley Brothers prod. by The Isley Brothers
- Sensuality (Pts. 1 & 2) by The Isley Brothers prod. by The Isley Brothers
- Serve You Right by Isley Jasper Isley prod. by Chris Jasper & Marvin Isley
- Settle Down by The Isley Brothers (Ft. Angela Winbush) prod. by James "Big Jim" Wright & Jimmy Jam & Terry Lewis
- Sex Drive by Isley Jasper Isley prod. by Chris Jasper & Marvin Isley
- SHE SO by Kalan.FrFr prod. by Mike Hector
- Sideway Shuffle by Joss Stone prod. by Joss Stone, Steve Greenberg & Steve Greenwell
- Slow Is the Way by The Isley Brothers prod. by Keith Sweat
- Slow Jams Interlude (Live at the North Sea Jazz Festival, 2005) by Common prod. by DJ Dummy, Karriem Riggins & My Guy Mars
- Something To Prove by H.E.R. prod. by David Harris, Flippa, JProof, OAK & Pop Wansel
- Southside Royalty Freestyle by Megan Thee Stallion (Ft. Big Pokey, Lil' Keke, Mike D & Sauce Walka) prod. by Juicy J & Mr. Lee
- So You Wanna Stay Down by The Isley Brothers prod. by The Isley Brothers
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