- Schuyler Defeated by Anthony Ramos, Leslie Odom, Jr., Lin-Manuel Miranda & Phillipa Soo prod. by Alex Lacamoire, Bill Sherman, Lin-Manuel Miranda & ?uestlove
- Section by The Roots prod. by Grand Wizzards & Kelo Saunders
- S.G.G. by Thouxanbanfauni prod. by Chinatown & MilanMakesBeats
- Silent Treatment by The Roots prod. by Grand Wizzards
- Silent Treatment (Beatminerz Remix) by The Roots prod. by Da Beatminerz
- Singing Man by The Roots (Ft. Dice Raw, Greg Porn & Truck North) prod. by Khari Mateen & The Roots
- Sleep by The Roots (Ft. Son Little) prod. by Hot Sugar & ?uestlove
- Slow Down by Chiddy Bang (Ft. eLDee the Don) prod. by Xaphoon Jones
- Somebody's Gotta Do It by The Roots (Ft. Devin The Dude, Jean Grae & Mack dub) prod. by Tahir
- Sometimes by Danger Mouse & Black Thought prod. by Danger Mouse
- Soundtrack to Confusion prod. by Salaam Remi
- Star/Pointro by The Roots (Ft. Wadud Ahmad) prod. by ?uestlove
- State Prisoner prod. by Sean C
- Stay Alive by Original Broadway Cast of Hamilton prod. by Alex Lacamoire, Bill Sherman, Lin-Manuel Miranda & ?uestlove
- Stay Alive (Reprise) by Lin-Manuel Miranda, Anthony Ramos, Phillipa Soo & Original Broadway Cast of "Hamilton" prod. by Alex Lacamoire, Bill Sherman, Lin-Manuel Miranda & ?uestlove
- Stay Cool by The Roots (Ft. Martin Luther) prod. by Mel "Chaos" Lewis
- Steak Um (Ft. ScHoolboy Q) prod. by Sean C
- Step Into the Realm by The Roots prod. by Grand Wizzards & The Roots
- Stolen Moments Pt. II by Common prod. by No I.D.
- Stomp by The Roots (Ft. Greg Porn) prod. by Sean C & LV