Even at my low bitch I'm high, I'm tryna stay focused I'm fine

from Lil Wayne – Wish You Would (Dedication 4) Lyrics on Rap Genius

Think of this line
“Me fallin' off is like you dropping a hit song"
His musical talent is so great that his "low” is a high for most others.
Also, he is always smokin' weed so if he were to ever fall off (like some people say he has) he would still be high because of that kush.

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