And I go off the feds when I'm scrambling at night

from Cam'ron (Ft. Jay Z & Juelz Santana) – Welcome to New York City Lyrics on Rap Genius

Meaning

If you assume there’s an “on” after “off” in this line, it makes more sense: when he’s running from federal agents at night he fires guns at them (goes off on them with his guns)

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