Born to lose, built to win
He’s referring to African Americans as a whole. Superior races never wanted blacks to have anything, so from birth they were destined to be losers (dealing with poverty, skin color dominance, etc). However, through their battle with racial struggles they have proven otherwise (mentally and physically).
To help improve the meaning of these lyrics, visit “Heaven’s Afternoon” by Wale (Ft. Meek Mill) Lyrics and leave a comment on the lyrics box