Trying to come up off of me, you in the clouds hoping
Smoking dope. It's like a Sherm-high
Niggas think they learned to fly

from 2Pac (Ft. Outlawz) – Hit 'Em Up Lyrics on Rap Genius

Meaning

Biggie and others think they can imitate Pac’s style and get rich off it. They must be high from smoking “sherm” (PCP), which is known for making users think they can fly.

In some circles “Sherm” = regular joints dipped in this:

A little different than PCP.

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