I can’t tell you what's good, but I can tell you what's what

from Game (Ft. Lil Wayne) – Red Nation Lyrics on Rap Genius

Meaning

Moral relativism/ambiguity as conveyed by Lil Wayne.

“What’s good” is usually used in the sense of “What’s up,” but here Wayne seems to be taking it more literally (i.e. good as “right” or “morally just”). In other words, he is not sure what is right, but he is aware of what’s happening around him.

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