You see your little nosy-ass homegirls, done got your ass sent up the creek
G, without a paddle, you left to straddle and ride this thing on out
“Up the creek without a paddle” is a phrase meaning you are in a an extremely difficult situation. In this case, Big Boi’s baby mama is the one of the creek without a paddle, and it was brought upon by her nosy friends that wouldn’t stay out of her business. But there’s nothing she can do about it, she still has to “ride it out” until it’s over.
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