Ish bowled two 6's twice, I couldn't go to sleep

from Wu-Tang Clan (Ft. Isaac Hayes) – I Can't Go To Sleep Lyrics on Rap Genius

Meaning

This refers to the casino gambling game, craps. If one rolls a 2, 3, or 12 then they lose, so getting 2 6’s twice is frankly quite unlucky, and something Ghost perceives as a bad omen

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