Man, I come down in a couple of days
In relation to the previous line, Lil Wayne is so high that it will take him a couple of days to get back to his normal state.
On another note, this single was realesed right before Weezy went to prison. So he might have been talking about him going to a new low: prison/Hell.
To help improve the meaning of these lyrics, visit "No Love" by Eminem (Ft. Lil Wayne) Lyrics and leave a comment on the lyrics box