That's why I don't fuck with the big four-O

from Cypress Hill – Insane in the Brain Lyrics on Rap Genius


He’s likely talking about 40’s of beer.

In the American vernacular, a forty-ounce or simply forty is a glass bottle that holds 40 fluid ounces (1.18 litres) of liquor, B-real is saying that he don’t mess with the liquor.

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