I'm learning all the potholes in every single barrio
This relates to the previous line about dating models. The “barrio” (Spanish for neighborhood) sounds a lot like “body,” which is how it’s being used in this metaphor.
P.S. By “pothole” he means “vagina”
To help improve the meaning of these lyrics, visit "Guns & Roses" by Jay-Z (Ft. Lenny Kravitz) Lyrics and leave a comment on the lyrics box