Yo, I'm from the ghetto where there's special enhancements
Niggas begin to shoot and don't get second chances

from Mellowhype – Loco Lyrics on Rap Genius

Meaning

There’s an extra standard in the ghetto, cause you only get one chance to shoot.

Also, a reference to the last line of first person shooters. In Call of Duty, there is a perk that gives you the ability to stay alive after you would have been killed. You are given a second chance where you are wounded on the ground with only a pistol.

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