Wicked as 80 reverends in a pool of fire with devils holding hands
From the distance, don’t know which one is a Christian.. damn
Who can I trust in 2012? There’s no one not even myself
A Gemini screaming for help, somebody

from Kendrick Lamar – Hol' Up Lyrics on Rap Genius

Meaning

Not only does he act mature for his age, he’s as wicked as throwing Christains and devils in a pool of fire. From down the block you wouldn’t be able to tell the difference between the Christian and devil. Now that it’s 2012 you cant even trust yourself. people need to stay focused. He feels because of all the crazy wickedness he screams for help hoping someone will hear. Its as tho nobody is around.

ALTERNATIVELY: From a distance he’s seeing hell and he doesn’t know who to trust before he gets to it (the end of the world in 2012), ‘cause the preachers and devils look the same.
I think Gemini, the sign commonly denoted by twins, alludes to the double/multiple personality Gemini supposedly have according to astrology. Therefore, he’s talking about not being able to trust himself/his 'twin’/other part of himself before he gets there.

More directly, since Kendrick’s birthday is June 17, his sign is Gemini.

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