Is anybody out there? It feels like I'm talking to myself
No one seems to know my struggle, and everything I've come from
Can anybody hear me? Yeah, I guess I keep talking to myself
It feels like I'm going insane, am I the one who's crazy? Yeah

from Eminem (Ft. Kobe) – Talkin' 2 Myself Lyrics on Rap Genius

Meaning

Perhaps Em voicing his frustrations through Kobe on his loneliness and confusion during his drug induced era.

To help improve the meaning of these lyrics, visit “Talkin' 2 Myself” by Eminem (Ft. Kobe) Lyrics and leave a comment on the lyrics box