Get that mic out your hand we don't know where your mouth has been

from Joell Ortiz (Ft. Brother Ali, Jean Grae & Talib Kweli) – So Wrong Lyrics on Rap Genius

Meaning

Following his previous childhood phrase with a variation of another familiar saying:
original
“Don’t put that in your mouth, you don’t know where it’s been”

But to Ali, and most MC’s, the mic is a coveted object that should be handled with respect. The scrubs who trying to rap for Brother Ali get declined.

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