It, I can't hold it,

from Kanye West (Ft. Nas & Really Doe) – We Major Lyrics on Rap Genius

Meaning

When smoking weed, you’re supposed to hold it in for as long as possible to take the best hit. He’s saying he can’t hold this hit in any longer ‘cause it’s too good. The hit he’s talking about could be this track or weed or both.

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