Can't block or screen that shit,

from Game (Ft. Kendrick Lamar) – The City Lyrics on Rap Genius

Meaning

You can’t stop Kendrick from keeping it real.
In basketball, blocks stop the other team from scoring and screens help stop the defense from preventing scores.

This line also means that you can’t censor Kendrick (or the harsh realities of Compton). Block means, obviously, to stop something from being shown, and screen means to view material previous to airing it in order to make sure that the content is appropriate.

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