I’ll do it all again if I had the chance
Don’t feel the pain (don’t feel the pain)
Like novacane (like novacane)
I’ll take the whole world on, I’m feeling so strong
Don’t feel the pain (don’t feel the pain)
Like novacane (like novacane)
Like novacane

from Lil Wayne (Ft. Kevin Rudolf) – Novacane Lyrics on Rap Genius

Meaning

If he had the chance, he would use coke again because it made him feel strong enough to take the whole world on.

He compares a hit of cocaine to the medical drug, novacaine, which also numbs pain.

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