Get me off of this, I need confidence in myself
The Weeknd references depression and addiction a lot. This is a cry for help. He is asking her, and quite possibly the listener, to help him kick his habit and re-gain the confidence in himself he lacks.
Though this may suffice as a reference to drug addiction, it is more than likely Abel hoping that meaningless sex with a stranger and ‘'getting off’‘ will ’‘get him off’‘ a deep spiraling depressive episode.
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