Who woulda ever think she'd rather do us up
But that's the business,

from Ghostface Killah (Ft. The Notorious B.I.G. & Raekwon) – Three Bricks Lyrics on Rap Genius

Meaning

Who would have thought that it would be a girl who tries to rob/kill Frank and Lex? Its just part of what happens in the life of crime.

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