And your back hurt, and your neck hurt, and you smoking heavy
And I sit next to you, and I lecture you because those are deadly

from Drake – Look What You've Done Lyrics on Rap Genius

Meaning

His mom was in a lot of pain, and she’s smoking cigarettes, but Drakes mom was the most important thing in his life, so he had to tell her to stop.
Drake’s mom has been dealing with a condition for a few years, the specifics were never released. In a semi-recent interview Drake describes how the piece of bone holding Sandi’s neck and her spine together was withering away. http://www.youtube.com/watch?v=tbprrUaxWuY

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