That I'm his number one fan
But its like you booing from the stands

from Lupe Fiasco (Ft. Gemini & Sarah Green) – He Say She Say Lyrics on Rap Genius

Meaning

His dad is booing him while his mom is trying to cheer him on.

Even though his mother is supportive (his #1 fan) his dad’s lack of support (booing) is taking a toll. This connects with the “why don’t you give him a chance” line because people tend to boo performers they don’t like when they get on stage often without giving them a chance to actually perform. In this case, the stage MYH is on is ‘life’ and his mom wants the dad to stop booing and give MYH a chance to succeed.

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