You're on 22nd, hit you from two-one
That's on Lenox, 7th Ave was News One

from Cam'ron (Ft. Jay Z & Juelz Santana) – Welcome to New York City Lyrics on Rap Genius

Meaning

If you’re on 122nd street and Lenox Avenue, Cam’s gun is powerful enough to hit you from a block away (121st), not on 7th Avenue, where the News One headquarters are.

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