Chrome gleaming like the dome off Keenan
from Jay-Z (Ft. Missy Elliott & Twista) – Is That Yo Bitch? Lyrics on Rap Genius
Meaning
Twista has chrome, either on his vehicles, or on his weapon (although a chrome weapon would more than likely be Nickel) and said chrome is reflective like Keenan Ivory Wayans bald head.
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