All I need in this life of sin, is me and my girlfriend
Down to ride to the bloody end, just me and my girlfriend

from 2Pac – Me and My Girlfriend Lyrics on Rap Genius

Meaning

The only woman that Tupac could trust is his gun. As such, he wants to spend his time with his gun, since he can always count on his gun to defend him till the death.

The irony of this of course, is that Tupac didn’t take his girlfriend to Las Vegas. The album this song was on came out posthumously and the reality of his death is that the car he was riding was boxed in. Nobody did anything to defend Tupac.

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