The little boy said what happened to all the girls
The preacher man said she's going to kill off your soul
The dope boy said it's the whole wide world
Lupe is referring back to the end of his first verse by showing on how, at the end of the virus outbreak, everyone has different theories on how how much of the world has died. The little boy sees all of the little girls gone (dead), and the drug dealer believes that the entire world has been infected.
Its sounds like he is talking about the woman or a whore. “The little boy said what happened to all the girls”, they became whores. “the preacher man sad she’s gonna kill off your soul” lust will lead to hell. “The dope boy said its the whole wide world”, i think this one is about the world being a bitch. “and if the world was a bitch I’d stick my dick in the ground, Fuck the world” <– that concept or mentality.
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