And, I told your ho my chain so cold it's on Theraflu
Chains are made of diamonds which rappers call ICE. So if he has a chain, he has ice on him, and ice is cold (obviously).
But these diamonds he wears are so cold (the more expensive, the colder) that they can get constipated and need medicine — Theraflu , which is a medicine for flu.
Also a refference to the previous line when he mentioned Sub-Zero and to Kanye West’s recent track “Way Too Cold”, which was first named Theraflu. Oh, and 2 Chainz is now a member of Kanye’s crew, G.O.O.D. Music.
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