Nobody knew how deep it screwed me
And since my pops never knew me
My family didn't know what to do with me

from 2Pac – The Streetz R Deathrow Lyrics on Rap Genius

Meaning

nobody really knew how deep it screwed his mind up not having his father and his mother together. his father split when he was young (maybe not even born yet) and he never had chance to meet him so he never had a father figure or a role model to follow and help him become a man so he made himself a man by doing “grown” man stuff. (insert gang violence here) His family couldn’t understand him because none of them knew what he was going through so they couldn’t find a way to help him and din' know what to do with him.

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