Regardless of who you pick know life's a bitch when you ain't focused nigga

from Talib Kweli (Ft. Curren$y & Kendrick Lamar) – Push Thru Lyrics on Rap Genius

Meaning

This line (like in Nas’s “Life’s a Bitch”) personifies life as a woman. Kendrick is saying that regardless of if you made life your wife or your mistress, she (it) will be a bitch if you aren’t astute and vigilant.

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